Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Hydroxy-2-pentanone → 6-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)-2-(4-oxopentyloxy)-4-(trifluoromethyl)nicotinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Hydroxy-2-pentanone | HCID 14066 | — |
| 반응물 | 2,6-Dichloro-4-(trifluoromethyl)nicotinamide | HCID 2736874 | — |
| 반응물 | 1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-ol | HCID 57968699 | — |
| 생성물 | 6-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)-2-(4-oxopentyloxy)-4-(trifluoromethyl)nicotinonitrile | HCID 66726636 | — |
반응 단계
This compound was prepared from 2,6-dichloro-4-(trifluoromethyl)nicotinamide, 5-hydroxypentan-2-one, and benzo[c][1,2]oxaborole-1,5(3H)-diol in a similar manner to that of D230. 1H-NMR (400 MHz, DMSO-d6) δ (ppm) 1.85-1.88 (m, 2H), 1.93 (s, 3H), 2.95-2.99 (t, J=4.9 Hz, 2H), 3.91-3.94 (t, J=5.4 Hz, 2H), 5.01 (s, 2H), 7.21 (dd, J=6.0, 1.5 Hz, 1H), 7.3 (s, 1H), 7.64 (s, 1H), 7.81 (d, J=6.0 Hz, 1H), 9.26 (s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09145429B2 |
| 출처 데이터셋 | uspto-grants-2015_09 |
| ORD ID | ord-2cb8f676249f444cbb9819f63f821c73 |
| 출처 메모 | uspto-grants-2015_09 |