참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Hydroxybenzophenone | HCID 83050 | — |
| 반응물 | 4-Chloro-6,7-dimethoxyquinoline | HCID 459610 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | {3-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}phenylmethanone | HCID 53907205 | 65.3% |
반응 단계
4-Chloro-6,7-dimethoxyquinoline (112 mg) and 3-hydroxybenzophenone (297 mg) were mixed together, and the mixture was heated at 170° C. for 10 min. A saturated aqueous sodium hydrogencarbonate solution was added thereto, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, was dried over sodium sulfate, and was then concentrated. The residue was subjected to separation and purification by column chromatography on silica gel using hexane-acetone as a solvent to give the title compound (126 mg, yield 65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07560558B2 |
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| 출처 데이터셋 | uspto-grants-2009_07 |
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| ORD ID | ord-7f9cab0a07a442abbf9e7ddac8cc2348 |
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| 출처 메모 | uspto-grants-2009_07 |
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