Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(3-pyridyl)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Ethyl 3-{(1-(3-nitrophenyl)-5-oxopyrrolidin-3-yl) carbonylamino}-3-(3-pyridyl)propanoate | HCID 22591756 | — |
| 촉매 | Zinc | HCID 23994 | — |
| 용매 | Methanol tetrahydrofuran water | HCID 21892291 | — |
| 생성물 | Ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(3-pyridyl)propanoate | HCID 10200775 | — |
반응 단계
Ethyl 3-{(1-(3-nitrophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(3-pyridyl)propanoate was dissolved in THF/MeOH/H2O solution at 0° C. AcOH was added followed by activated Zn powder. The reaction was then stirred at room temperature for 5 hours. The Zn powder was filtered through a pad of celite. The filtrate was concentrated in vacuo and the residue was re-dissolved in EtOAc. A white precipitate formed and was removed by filtration. The organic solution was concentrated in vacuo to afforded yellow foam. MS (ES+): 397.0 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06849639B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-e12380c8349b4d6cb255b86ce00751ee |
| 출처 메모 | uspto-grants-2005_02 |