Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1(2H)-Isoquinolinone → 4-Chloro-1(2H)-isoquinolone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1(2H)-Isoquinolinone | HCID 10284 | — |
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | 1,4-Dichloroisoquinoline-7-sulfonyl chloride | HCID 16658294 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-Chloro-1(2H)-isoquinolone | HCID 824649 | — |
반응 단계
1,4-Dichloro-7-isoquinolinesulphonyl chloride ##STR107## A solution of N-chlorosuccinimide (9.66 g, 72 mmol) in MeCN (80 mL) was added dropwise to a stirred solution of 1-(2H)-isoquinolone (10 g, 69 mmol) in MeCN (250 mL) which was being heated under reflux. The mixture was heated under reflux for an additional 1.5 h and then cooled to room temperature. The resulting precipitate was collected by filtration, with MeCN rinsing, and then dried in vacuo to give 4-chloro-1(2H)-isoquinolone (11.3 g, 62.9 mmol) as a pale pink solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06093731 |
| 출처 데이터셋 | uspto-grants-2000_07 |
| ORD ID | ord-74292bf0419c4ab89d23b0e9d23420d9 |
| 출처 메모 | uspto-grants-2000_07 |