Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-(Dimethylamino)piperidine dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 반응물 | Triacetoxyborohydride | HCID 2724942 | — |
| 반응물 | 4-Boc-piperidinone | HCID 22318161 | — |
| 반응물 | Tert-butyl 4-(dimethylamino)piperidine-1-carboxylate | HCID 22591376 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 4-(Dimethylamino)piperidine dihydrochloride | HCID 22591440 | — |
반응 단계
Dimethylamine hydrochloride (430 mg) was added to a methylene chloride (10 ml) solution containing 4-(tert-butoxycarbonyl)piperidone (1.0 g), and under ice-cooling, triethylamine (0.84 ml) and triacetoxyborohydride (1.17 g) were further added thereto, and the mixture was stirred at room temperature for 3 hours to undergo reaction, thereby obtaining N-tert-butoxycarbonyl-4-dimethylaminopiperidine. This compound was acid-treated with hydrochloric acid to obtain 4-(dimethylamino)piperidine.dihydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06849622B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-2a621ec232ee49fcbfb7856de2c1ed48 |
| 출처 메모 | uspto-grants-2005_02 |