Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoic Acid → N-(piperidin-4-yl)benzamide hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoic Acid | HCID 243 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(piperidin-4-yl)benzamide hydrochloride | HCID 21942082 | — |
반응 단계
A mixture comprising 4-amino-1-(tert-butoxycarbonyl)piperidine (700 mg), benzoic acid (512 mg), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (804 mg), 1-hydroxybenzotriazole (567 mg) and N,N-dimethylformamide (10 ml) was stirred at room temperature for 16 hours to undergo reaction, and the resulting compound was acid-treated with hydrochloric acid to obtain 4-(benzoylamino)piperidine.hydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06849622B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-896dc73da64e41a0937ff5ca2ca0765c |
| 출처 메모 | uspto-grants-2005_02 |