Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Dibromobutane → Ethyl 2-(4-bromobutoxy)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Dibromobutane | HCID 8056 | — |
| 반응물 | Ethyl Glycolate | HCID 12184 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl 2-(4-bromobutoxy)acetate | HCID 20436843 | — |
반응 단계
To a solution of sodium hydride in 40 mL DMF stirred at 0° C. was slowly added ethyl glycolate (5 g, 48 mmol). After 1 hour, 1,4-dibromobutane (8.6 mL, 72 mmol) was added, and the mixture was stirred for an additional 2 hours. The reaction was allowed to warm to room temperature for an additional 3 hours. A sodium bicarbonate solution was added, and the organic layer was dried over anhydrous sodium sulfate, concentrated and the residue was purified by chromatography to afford a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06849657B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-ab789f9d1df541f2bbe68664d376d405 |
| 출처 메모 | uspto-grants-2005_02 |