Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl acetoacetate → 1-(Rac)-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-5-(2-fluoro-5-trifluoromethyl-phenyl)-2-methyl-1h-pyrrole-3-carboxylic acid ((1r,2r)-2-hydroxy-cyclohexyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl acetoacetate | HCID 7757 | — |
| 반응물 | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| 반응물 | 2-Fluoro-5-(trifluoromethyl)phenacyl bromide | HCID 2778784 | — |
| 반응물 | 1,3-Dioxolane-4-methanamine, 2,2-dimethyl- | HCID 4122349 | — |
| 생성물 | 1-(Rac)-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-5-(2-fluoro-5-trifluoromethyl-phenyl)-2-methyl-1h-pyrrole-3-carboxylic acid ((1r,2r)-2-hydroxy-cyclohexyl)-amide | HCID 11656235 | — |
반응 단계
The title compound was synthesized in analogy to example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-[2-fluoro-5-(trifluoromethyl)-phenyl]-ethanone as compound of formula S, 2,2-dimethyl-1,3-dioxolan-4-methylamine as R3—(CH2)m—NH2 and (1R,2R)-2-aminocyclohexanol as R1R2NH, MS (ISP) 499.5 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07563910B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-263ddf3c7db74a4dafa89ecc3e47e864 |
| 출처 메모 | uspto-grants-2009_07 |