Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → N-(3,4-dichlorophenyl)glycine Iso-butyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | t-Butyl carbanilate | HCID 137930 | — |
| 반응물 | 2-Methylpropyl 2-bromoacetate | HCID 521906 | — |
| 반응물 | N-BOC N-(3,4-dichlorophenyl)glycine iso-butyl ester | HCID 54479293 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(3,4-dichlorophenyl)glycine Iso-butyl Ester | HCID 9925559 | — |
반응 단계
3,4-Dichloroaniline (Aldrich) was treated with di-tert-butyl dicarbonate (Aldrich) using conventional procedures to produce the N-BOC aniline. The N-BOC aniline was treated with sodium hydride in THF and then with iso-butyl 2-bromoacetate (from Example AD above) to produce the N-BOC N-(3,4-dichlorophenyl)glycine iso-butyl ester. The BOC group was then removed using General Procedure AN above to afford the title compound. The reaction was monitored by tlc on silica gel (Rf=0.78 in 50% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 50% EtOAc/hexanes as the eluant).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06849650B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-2ac91e5641454fa899ee52397056ea0e |
| 출처 메모 | uspto-grants-2005_02 |