참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | 2-(3-Methoxy-allylidene)-malonic acid dimethyl ester | HCID 597992 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (E)-Dimethyl 2-(3-(phenylamino)allylidene)malonate | HCID 59852887 | 57.4% |
반응 단계
To a solution of 2-(3-methoxyallylidene)malonic acid dimethyl ester (Acros Organics, 200 mg, 1.0 mmol) in THF (2 mL) at rt was added aniline (300 mg, 3.2 mmol) and the reaction mixture was heated at 60° C. for 8.5 h. Purification of the reaction mixture by preparative HPLC afforded the desired product (150 mg, 57%) as a yellow solid. 1H NMR (DMSO-d6) δ 10.16 (d, 1H, J=12.7Hz), 8.06 (t, 1H, J=12.7 Hz), 7.74 (d, 1H, J=12.7 Hz), 7.30 (t, 2H, J=8.7 Hz), 7.16 (d, 2H, J=7.7 Hz), 6.98 (t, 1H, J=7.7 Hz), 6.35 (t, 1H, J=12.1 Hz), 3.69 (s, 3H), 3.65 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07566784B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-518c57da93a047a7929bf4b86a5a0992 |
|---|
| 출처 메모 | uspto-grants-2009_07 |
|---|
