Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 3-Methyl-2,3-dihydrobenzofuran-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 2,2,2-Trifluoro-N-(3-methyl-2,3-dihydro-1-benzofuran-4-yl)acetamide | HCID 57763285 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Methyl-2,3-dihydrobenzofuran-4-amine | HCID 54326406 | 92.6% |
반응 단계
To a stirred solution of Intermediate 24 (0.087 g) in 2:2:1 tetrahydrofuran:methanol:water (5 ml) was added lithium hyroxide (0.149 g) and the mixture stirred at room temperature for 47 h, then at 60° C. for 2.5 h. The solvent was removed in vacuo and the residue partitioned between ethyl acetate and water. The aqueous layer was re-extracted with dichloromethane and the combined organic layers dried over sodium sulphate and concentrated in vacuo to give the title compound as a colourless oil (0.049 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07566786B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-d19e96b5ee8d4e5d9df787ed25d61f4d |
| 출처 메모 | uspto-grants-2009_07 |