Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → HCID 20030580, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 1,1,2-Trichloroethanol | HCID 119427 | — |
| 반응물 | HCID 23690323 | HCID 23690323 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 20030580 | HCID 20030580 | 78% |
반응 단계
Oxalyl chloride (2.8 g; 0.022 mol) is added to a suspension of compound 3 (4.1 g; 0.022 mol) in dichloromethane (50 cc). The mixture is heated under reflux until gas evolution ceases and then treated with a solution of trichloroethanol (3.3 g; 0.022 mol) and pyridine (3.5 g; 0.044 mol) in dichloromethane (30 cc). The mixture is then treated with water and then dried. After evaporation of the solvent and crystallization in pentane, 2,2,2-tri-chloroethyl 2-cyanonicotinate (4.55 g; m.p. 103° C.) is obtained (yield=78%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04851396 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-be80054748d5446480496c5b8647d737 |
| 출처 메모 | uspto-grants-1989_07 |