Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(2,6-Dichlorophenyl)acetyl chloride → 3'-O-benzyl-5'-[2-(2,6-dichlorophenyl)acetamido]2',5'-dideoxy-5-ethyluridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(2,6-Dichlorophenyl)acetyl chloride | HCID 2758148 | — |
| 반응물 | 5'-amino-3'-O-benzyl-2',5'-dideoxy-5-ethyluridine | HCID 18633459 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 3'-O-benzyl-5'-[2-(2,6-dichlorophenyl)acetamido]2',5'-dideoxy-5-ethyluridine | HCID 18633399 | — |
반응 단계
A solution of (2,6-dichlorophenyl)acetyl chloride (prepared from 103 mg of the acid) in 2 ml of diethyl ether was added to a solution of 173 mg of 5'-amino-3'-O-benzyl-2',5'-dideoxy-5-ethyluridine in 4.5 ml of 0.11M sodium hydroxide solution. The mixture was shaken vigorously for 10 minutes and then filtered. The solid was recrystallized from ethanol to give 120 mg of 3'-O-benzyl-5'-[2-(2,6-dichlorophenyl)acetamido]-2',5'-dideoxy-5-ethyluridine in the form of a white solid of melting point 174°-177° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04851519 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-234aa9b0397c47b49f76d83ad870af51 |
| 출처 메모 | uspto-grants-1989_07 |