Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → Benzilic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | Bis(4-fluorophenyl)(hydroxy)acetic acid | HCID 12068839 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Benzilic acid | HCID 6463 | — |
반응 단계
25.0 g (0.095 mol) of 4,4′-difluorobenzilic acid is added to freshly prepared sodium ethoxide solution containing 2.17 g (0.095 mol) of sodium and 200 ml of ethanol at 20° C. and stirred for 3 hours. The solution is evaporated to dryness, the residue is dissolved in DMF, 22.57 g (0.16 mol) of methyl iodide is added dropwise at 20° C., and the mixture is stirred for 24 hours. It is worked up and purified analogously to compound 12b. Yield: 21.06 g (80% of theory).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06852728B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-aef3a9165c004a55b2384744041b864a |
| 출처 메모 | uspto-grants-2005_02 |