Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 5-Chloro-3-hydroxy-3-(2-methoxyphenyl)indolin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 2-Bromoanisole | HCID 11358 | — |
| 반응물 | 5-chloro-1H-indole-2,3-dione | HCID 87203 | — |
| 반응물 | Magnesium | HCID 5462224 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 5-Chloro-3-hydroxy-3-(2-methoxyphenyl)indolin-2-one | HCID 21905955 | — |
| 생성물 | HCID 178489560 | HCID 178489560 | — |
반응 단계
A solution of 2-methoxyphenylmagnesium bromide is prepared from 1.35 g of magnesium and 10.5 g of 1-bromo-2-methoxybenzene in 100 ml of ether. This solution is added in 10 minutes at RT, under an argon atmosphere, to a mixture of 4.1 g of 5-chloroisatin and 70 ml of THF. After stirring for 1 hour at RT, water is added and the product is filtered off, redissolved in THF, dried over magnesium sulfate and evaporated under vacuum in the presence of iso ether. The residue is chromatographed on silica using a DCM/AcOEt mixture (60/40; v/v) as the eluent to give the expected product after crystallization from a THF/iso ether mixture.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05594023 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-af335294599a403084827c600955337f |
| 출처 메모 | uspto-grants-1997_01 |