Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → (Z)-2-(3,4-dimethoxy-phenyl)-3-(5-morpholin-4-yl-furan-2-yl)-acrylonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 3,4-Dimethoxybenzeneacetonitrile | HCID 66727 | — |
| 반응물 | 5-Bromofuran-2-carbaldehyde | HCID 600328 | — |
| 반응물 | 5-Morpholin-4-yl-2-furaldehyde | HCID 602308 | — |
| 생성물 | (Z)-2-(3,4-dimethoxy-phenyl)-3-(5-morpholin-4-yl-furan-2-yl)-acrylonitrile | HCID 11965418 | 40% |
반응 단계
Through the procedure as employed in Production step 1, an amine moiety derived from morpholine (523 mg) was introduced into 5-bromo-2-furaldehyde (350 mg), to thereby yield 5-morpholin-4-yl-furan-2-carbaldehyde (yield: 138 mg, 38%). The produced 5-morpholin-4-yl-furan-2-carbaldehyde (137 mg) was condensed with 3,4-dimethoxybenzyl cyanide (135 mg) through Method A (production step 2), to thereby yield the target product (yield: 102 mg, 40%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08697742B2 |
| 출처 데이터셋 | uspto-grants-2014_04 |
| ORD ID | ord-232e68d47d28499b903c549e398ca29b |
| 출처 메모 | uspto-grants-2014_04 |