Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2370567생성일: 2026년 10월 24일
Diisopropylethylamine → N-methyl-4-(2-(4-((4-methylpiperazin-1-yl)methyl)benzylamino)benzo[d]thiazol-6-yloxy)picolinamide
https://huagongshe.com/ko/reaction/2370567
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-((4-Methyl-1-piperazinyl)methyl)benzenemethanamine | HCID 7537610 | — |
| 반응물 | 2-Pyridinecarboxamide, N-methyl-4-[[2-(methylsulfinyl)-6-benzothiazolyl]oxy]- | HCID 57725393 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | N-methyl-4-(2-(4-((4-methylpiperazin-1-yl)methyl)benzylamino)benzo[d]thiazol-6-yloxy)picolinamide | HCID 57725947 | — |
반응 단계
To the solution of N-methyl-4-(2-(methylsulfinyl)benzo[d]thiazol-6-yloxy)picolinamide (25 mg, 0.072 mmol, 1.0 eq) in 2 mL of NMP was added (4-((4-methylpiperazin-1-yl)methyl)phenyl)methanamine (23 mg, 0.108 mmol, 1.5 eq) and DIPEA (37 μL, 0.216 mmol, 3.0 eq) and reaction mixture heated at 80° C. in oil bath for 12 hours. Thereafter, the product was purified via reverse phase HPLC. LC/MS (m/z) [503.1] (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08710048B2 |
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| 출처 데이터셋 | uspto-grants-2014_04 |
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| ORD ID | ord-b7eacda852484681bf66e7851f031d09 |
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| 출처 메모 | uspto-grants-2014_04 |
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