Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → (1R)-2-(methylamino)-1-pyrazin-2-ylethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | (1R)-1-(2-furyl)-2-(methylamino)ethanol | HCID 10214399 | — |
| 반응물 | HCID 69742350 | HCID 69742350 | — |
| 생성물 | (1R)-2-(methylamino)-1-pyrazin-2-ylethanol | HCID 10285809 | 79% |
반응 단계
As described for the preparation of (1R)-1-(2-furyl)-2-(methylamino)ethanol, the oxazolidinone (1.51 g, 8.43 mmol) is treated with 1N aq. KOH (42.1 mL, 5 equiv., 42.1 mmol ) to give (1R)-2-(methylamino)-1-pyrazin-2-ylethanol (1.02 g, 6.65 mmol) in 79% yield as a white solid. MP: 84-85° C.; Specific Rotation [α]D25+66 (c 0.94, methanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06852731B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-551598f4c36444969269f1c9883f2a71 |
| 출처 메모 | uspto-grants-2005_02 |