Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 1-Benzhydryl-3-methylazetidin-3-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1-(Diphenylmethyl)azetidin-3-one | HCID 3735558 | — |
| 반응물 | HCID 178418689 | HCID 178418689 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-Benzhydryl-3-methylazetidin-3-ol | HCID 10243989 | — |
반응 단계
To 1-benzhydryl-azetidin-3-one (1.0 g, 4.2 mmol) in ether (100 mL) at 0° C. was added CH3MgBr (1.5 mL, 3M in ether). The mixture was warmed to rt over 1 h and 1N NaOH (3 mL) was added. The organic layer was concentrated providing the title compound (1.1 g). MS (ESI): mass calcd. for C17H19NO, 253.2; m/z found, 254.2 [M+H]+. 1H NMR (CDCl3): 7.42-7.11 (m, 10H), 4.32 (s, 1H), 3.14 (d, J=8.5 Hz, 2H), 2.96 (d, J=8.5 Hz, 2H), 1.43 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642583B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-ba694aa1b8614138859310890ee21375 |
| 출처 메모 | uspto-grants-2014_02 |