Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 237284생성일: 2026년 10월 24일
Cyanomethylenetributylphosphorane → 1-Benzhydryl-3-[5-bromo-2-(3-chloro-benzyloxy)-phenoxy]-3-methyl-azetidine
https://huagongshe.com/ko/reaction/237284
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| 반응물 | 1-Benzhydryl-3-methylazetidin-3-ol | HCID 10243989 | — |
| 반응물 | HCID 67347295 | HCID 67347295 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-Benzhydryl-3-[5-bromo-2-(3-chloro-benzyloxy)-phenoxy]-3-methyl-azetidine | HCID 67348353 | 43.7% |
반응 단계
The mixture of the title compound from Step A (0.5 mmol), 5-bromo-2-(3-chloro-benzyloxy)-phenol (0.5 mmol), and cyanomethylenetri-n-butylphosphorane (0.5 mmol) in toluene (3 mL) was heated at 150° C. in a microwave reactor for 1 h. The mixture was cooled to rt and purified via PTLC providing the title compound (120 mg). MS (ESI): mass calcd. for C30H27BrClNO2, 547.1; m/z found, 548.0 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08642583B2 |
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| 출처 데이터셋 | uspto-grants-2014_02 |
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| ORD ID | ord-2459de9a057140f6bdde4ce0d97113d0 |
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| 출처 메모 | uspto-grants-2014_02 |
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