Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 2-(2-Oxopyrrolidin-1-yl)ethyl 4-methylbenzenesulfonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | 1-(2-Hydroxyethyl)-2-pyrrolidinone | HCID 76980 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(2-Oxopyrrolidin-1-yl)ethyl 4-methylbenzenesulfonate | HCID 44791207 | — |
반응 단계
p-Toluenesulfonylchloride (1 g) is added portionwise to a solution of 1-(2-hydroxyethyl)pyrrolidin-2-one (500 μL) and pyridine (1.5 mL) in dichloromethane (8 mL) chilled in an ice bath. The mixture is stirred at room temperature for 12 hours and partitioned between 1 M hydrochloric acid and diethylether. The organic phase is dried (MgSO4) and concentrated. The residue is chromatographed on silica gel (ethyl acetate) to give the title compound. Yield: 390 mg; Mass spectrum (ESI+): m/z=284 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642585B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-4062c828a452496db321125cd9fbf4e9 |
| 출처 메모 | uspto-grants-2014_02 |