Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-(trifluoromethyl)-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-(Trifluoromethyl)benzoyl chloride | HCID 75257 | — |
| 반응물 | 6-(1-aminoethyl)-N-(3,4,5-trimethoxyphenyl)-1,2,4-triazin-3-amine | HCID 53404429 | — |
| 반응물 | 2-nitro-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide | HCID 58711978 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(trifluoromethyl)-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide | HCID 58711986 | — |
반응 단계
In a similar manner as described for Intermediate 10, 6-(1-aminoethyl)-N-(3,4,5-trimethoxyphenyl)-1,2,4-triazin-3-amine (Intermediate 9) (0.085 g, 0.28 mmol), triethylamine (0.10 mL, 0.72 mmol) and 3-(trifluoromethyl)-benzoyl chloride (0.065 g, 0.31 mmol) in dichloromethane (5 mL) gave 3-(trifluoromethyl)-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide (0.12 g) as a yellow oil. MS m/z 478 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07462614B2 |
| 출처 데이터셋 | uspto-grants-2008_12 |
| ORD ID | ord-ddb6bdd4839e4bfb8c3d999247bbf56b |
| 출처 메모 | uspto-grants-2008_12 |