Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate → tert-Butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(4-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate | HCID 1514280 | — |
| 반응물 | tert-Butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(2-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate | HCID 59731884 | — |
| 반응물 | 3-Formyl-4-pyridinyl-2,2-dimethylpropanamide | HCID 86604792 | — |
| 생성물 | tert-Butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(4-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate | HCID 59732007 | 54% |
반응 단계
tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate (1.33 g, 5.2 mmol) and N-(3-formyl-4-pyridinyl-2,2-dimethylpropanamide (1.0 g, 4.7 mmol) were reacted in a manner analogous to the preparation of tert-butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(2-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate. Title compound was obtained as white foam in 54% yield. (M+H)+=464.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07470679B2 |
| 출처 데이터셋 | uspto-grants-2008_12 |
| ORD ID | ord-3a9b8dbcd5c84cf1b6fb84b58cd1dc73 |
| 출처 메모 | uspto-grants-2008_12 |