Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Fluoro-4-methanesulfonyl-2-nitrobenzene → 2-Fluoro-5-(methylsulfonyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Fluoro-4-methanesulfonyl-2-nitrobenzene | HCID 313137 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Adams' catalyst | HCID 345198 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Fluoro-5-(methylsulfonyl)aniline | HCID 2774637 | 111.7% |
반응 단계
A mixture of 4-fluoro-3-nitrophenyl methyl sulfone (Acros; 1.00 g; 4.56 mmol) and PtO2 (100 mg) in MeOH (150 ml) was placed in a PARR reactor and treated with a pressure of 20 atm of hydrogen for 3 hours. The reaction mixture was filtered through Celite and the filtrate was concentrated to dryness affording the title compound (964 mg) as a dark green oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08273769B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-f86a52444a864fd7bb82a00530047304 |
| 출처 메모 | uspto-grants-2012_09 |