참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Aminobenzenesulfonyl fluoride | HCID 66823 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-amino-N-methylbenzene-1-sulfonamide | HCID 74368 | 78.1% |
반응 단계
Methylamine (3 ml of a 33% solution in ethanol) and then triethylamine (0.159 ml, 1.1 mmol) was added to sulphanilyl fluoride (200 mg, 1.1 mmol), and the mixture heated at 80° C. for 6 hours then at ambient temperature for 18 hours. The volatiles were removed by evaporation and the residue azeotroped with toluene to give the title compound (160 mg, 76%). NMR: 2.30 (s, 3H), 5.85 (s, 2H), 6.60 (d, 2H), 7.39 (d, 2H); m/z: 187 [MH]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06855719B1 |
|---|
| 출처 데이터셋 | uspto-grants-2005_02 |
|---|
| ORD ID | ord-6672536baecc4bce82f56c30b796dbe9 |
|---|
| 출처 메모 | uspto-grants-2005_02 |
|---|
