Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 5-Imidazol-1-ylmethyl-quinolin-8-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 8-Quinolinol, 5-(chloromethyl)-, hydrochloride (1:1) | HCID 12269596 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 5-Imidazol-1-ylmethyl-quinolin-8-ol | HCID 594190 | 29% |
반응 단계
A mixture of 5-chloromethyl-8-hydroxyquinoline hydrochloride (3.45 g; 15 mmol), imidazole (1.02 g; 15 mmol) and diisopropylethylamine (5.25 ml; 30 mmol) in CHCl3 (60 ml) was stirred for 24 h at room temperature and then for 3 h at 60° C. After cooling, the mixture was evaporated, washed with ethyl acetate (50 ml) and then hexane (50 ml). The residue was crystallized from a mixture of toluene and ethanol (abs.) to give 0.83 g (29%) of title product. M.p. 182° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855711B1 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-1eb91e4390e4438fb90926e9ae38c271 |
| 출처 메모 | uspto-grants-2005_02 |