Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Nitrobenzenesulfonamide → N-(4-Nitrophenylsulphonyl)-4-[3-(2-benzyloxyphenyl),propyl]benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Nitrobenzenesulfonamide | HCID 22784 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 4-(3-(2-Benzyloxyphenyl)propyl]benzoic acid | HCID 18973764 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(4-Nitrophenylsulphonyl)-4-[3-(2-benzyloxyphenyl),propyl]benzamide | HCID 18973867 | 68.6% |
반응 단계
A mixture of 4-[3-(2-benzyloxyphenyl)propyl)benzoic acid 0.2 g), 4-nitrobenzenesulphonamide (0.12 g), DMAP (0.15 g) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.12 g) was stirred for 65 hours. The mixture was diluted with EtOAc, washed with water and brine, dried (MgSO4), filtered and evaporated. The residue was purified by flash chromatography on silica gel, eluting with ethyl acetate, to give the title compound (0.21 g) mpt. 112°-113° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05811459 |
| 출처 데이터셋 | uspto-grants-1998_09 |
| ORD ID | ord-88281c07bdd14ad4bf75ece76666dd74 |
| 출처 메모 | uspto-grants-1998_09 |