Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 6-methoxy-1H-indole-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Methyl-6-methoxy-2-indolecarboxylate | HCID 688173 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 6-methoxy-1H-indole-2-carboxylic acid | HCID 410327 | — |
반응 단계
Methyl 6-methoxyindole-2-carboxylate (PREPARATION 62, 5.71 g) is dissolved in 70 ml of dioxane and 7 ml of water and 1.87 g of crushed potassium hydroxide are added. The reaction is heated to 50° and stirred 1.5 hr. The reaction mixture is acidified to pH 4-5 and extracted several times with methanol/chloroform (10/90). The organic layers are combined and dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title acid, NMR (300 MHz, d4-CD3OD) 7.47, 7.08, 6.90, 6.72 and 3.82 δ.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05489593 |
| 출처 데이터셋 | uspto-grants-1996_02 |
| ORD ID | ord-8c6857bc23504724be8a8e74ef8e7d3c |
| 출처 메모 | uspto-grants-1996_02 |