Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-1,2,4-Triazole → (2R,3R)-2-(2,4-Difluorophenyl)-3-[6-methoxy-9(9H)-purinyl]-1-(1H-1,2,4-triazol-1-yl)-2-butanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-1,2,4-Triazole | HCID 9257 | — |
| 반응물 | (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl] oxirane | HCID 18657628 | — |
| 생성물 | (2R,3R)-2-(2,4-Difluorophenyl)-3-[6-methoxy-9(9H)-purinyl]-1-(1H-1,2,4-triazol-1-yl)-2-butanol | HCID 54133618 | 77.4% |
반응 단계
Using 1H-1,2,4-triazole (74 mg) and (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl]oxirane (183 mg), Compound 47 (171 mg) was obtained as colorless prisms by the same way as in Example 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05495024 |
| 출처 데이터셋 | uspto-grants-1996_02 |
| ORD ID | ord-198a67c4a6f14f15879b6f221928542f |
| 출처 메모 | uspto-grants-1996_02 |