Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → 1-Acetyl-4-(3-trifluoromethylbenzoyl)-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-(3-Trifluoromethylbenzoyl)piperidine | HCID 5086447 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 1-Acetyl-4-(3-trifluoromethylbenzoyl)-piperidine | HCID 21438407 | — |
반응 단계
To a solution of 32.1 g (0.125 mole) of 4-(m-trifluoromethylbenzoyl)piperidine in 75 ml of benzene and 21.2 g (0.2 mole) of Na2CO3, was added dropwise a solution of ten g (0.127 mole) of acetyl chloride in 75 ml of benzene. The mixture was refluxed for 2 hours. The mixture was filtered and the filtrate was concentrated under vacuum giving crude 1-acetyl-4-(m-trifluoromethylbenzoyl)piperidine. Yield 37.3 grams.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04021564 |
| 출처 데이터셋 | uspto-grants-1977_05 |
| ORD ID | ord-028b77b0d2ab4aa0986db2f9056a9a69 |
| 출처 메모 | uspto-grants-1977_05 |