Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(S)-(-)-1-Amino-2-(methoxymethyl)pyrrolidine → 5-cyclohexyl-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (S)-(-)-1-Amino-2-(methoxymethyl)pyrrolidine | HCID 7156993 | — |
| 반응물 | 5-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid | HCID 71293952 | — |
| 생성물 | 5-cyclohexyl-N-((S)-2-methoxymethyl-pyrrolidin-1-yl)-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxamide | HCID 71294024 | — |
반응 단계
The title compound was synthesized in analogy to Example 1 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid (example 12c) and (2S)-2-(methoxymethyl)-1-pyrrolidinamine (CAN 59983-39-0) as starting materials; LC-MS (UV peak area/ESI) 98.8%, 416.2159 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08648099B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-83f31f3ac5054a288462c3779695004d |
| 출처 메모 | uspto-grants-2014_02 |