Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenesulfonyl chloride → 1-Benzenesulfonyl-7-methoxy-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenesulfonyl chloride | HCID 7369 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 7-Methoxy-1H-indole | HCID 76660 | — |
| 반응물 | Water ethylacetate | HCID 22728543 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Benzenesulfonyl-7-methoxy-1H-indole | HCID 11778801 | — |
반응 단계
To a solution of 7-methoxyindole (1 eq) in DMF cooled in an ice bath was added NaH (60% dispersion in oil, 1.2 eq). The reaction was stirred for 1 hr at room temperature then recooled in an ice bath. Benzenesulfonyl chloride (1.1 eq) was added then the reaction was stirred for 2 hrs at room temperature. Water/ethyl acetate were added and the ethyl acetate layer was washed repeatedly (3×) with water. The ethyl acetate layer was concentrated and evaporated to dryness.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08648104B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-927b9b30e72649e2b62c4b069c86d747 |
| 출처 메모 | uspto-grants-2014_02 |