Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl bromoacetate → Ethyl 2-(4-methoxyphenyl)sulfanylacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl bromoacetate | HCID 7748 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Methoxybenzenethiol | HCID 12765 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 2-(4-methoxyphenyl)sulfanylacetate | HCID 1482371 | 92% |
반응 단계
To an ice-cooled mixture of 4-methoxythiophenol (15 g, 0.11 mol), triethylamine (28 mL, 0.20 mol) and tetrahydrofuran (150 mL) was added ethyl bromoacetate (21 g, 0.13 mol), and the mixture was stirred overnight at room temperature. Ethanol (10 mL) was added, the solvent was evaporated under reduced pressure, and the residue was partitioned between ethyl acetate and water. The organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=10:1) to give title compound (22 g, yield 92%). oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07960369B2 |
| 출처 데이터셋 | uspto-grants-2011_06 |
| ORD ID | ord-42d83b6449764e33977a6b0946c3f50d |
| 출처 메모 | uspto-grants-2011_06 |