Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → HCID 178455023, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1H-indazole | HCID 58042511 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | HCID 178455023 | HCID 178455023 | — |
반응 단계
To a stirred solution of 5-(tert-butyldimethylsilyloxy)-1H-indazole (5.3 g, 0.02 mol) in DMSO (50 mL) at 0° C., was added KOH (3.36 g, 0.06 mol) followed by iodine (10.2 g, 0.04 mol) portionwise. The mixture was stirred at room temperature for additional 10 minutes, then the reaction was quenched with 10% Na2S2O3 and diluted with water. The mixture was filtered and the filter cake was washed with water and dried to give 5-(tert-butyldimethylsilyloxy)-3-iodo-1H-indazole. The crude solid was used in the next step without purification. MS: (M+H)+=375.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08658646B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-141fc4217c0e4b0dbff96dcea8947c54 |
| 출처 메모 | uspto-grants-2014_02 |