Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-(2,6-Dimethoxyphenyl)ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | (3,5-Dimethoxyphenyl)acetic acid | HCID 138316 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 생성물 | 2-(2,6-Dimethoxyphenyl)ethanol | HCID 265633 | — |
반응 단계
A solution of (3,5-dimethoxy)phenylacetic acid (3 g) in Et2O (100 mL) was cooled to 0° C. and LiAlH4 (1M in Et2O, 16.8 mL) was added. The mixture was warmed to room temperature and stirred for 5 h, whereupon the pH was adjusted to 5 using HCl (1 M). The mixture was washed with H2O/EtOAc and the organic layer was separated. The aqueous layer was extracted with EtOAc. The combined organic layers were dried (MgSO4) and concentrated in vacuo to give 3,5-dimethoxy-4-(2-hydroxyethyl)benzene (2.8 g) as a crude product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855843B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-ae5a074dd2d144a895c715f5decbdd0e |
| 출처 메모 | uspto-grants-2005_02 |