Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl chloride → 2-Chloro-4-(3-benzoylthioureido)benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 반응물 | Ammonium thiocyanate | HCID 15666 | — |
| 반응물 | Methyl 4-Amino-2-chlorobenzoate | HCID 11839197 | — |
| 반응물 | Benzoyl thiocyanate | HCID 13203561 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Chloro-4-(3-benzoylthioureido)benzoic acid methyl ester | HCID 54229840 | — |
반응 단계
Benzoyl thiocyanate was generated by refluxing a solution of benzoyl chloride (0.31 mL) and ammonium thiocyanate (0.20 g) in acetone (15 mL) for 30 min. To this solution was added a solution of 4-amino-2-chlorobenzoic acid methyl ester (0.5 g) in CH3CN (10 mL) and the mixture was refluxed for 5 h. The solvent was removed and the residue was partitioned between CH2Cl2 and water. The organic layer was separated, washed with brine, dried and evaporated. The residue was purified by column chromatography to yield 2-chloro-4-(3-benzoylthioureido)benzoic acid methyl ester (0.71 g). ESMS: 349 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855843B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-5addadf8094e4a8f8757a7f561e58be7 |
| 출처 메모 | uspto-grants-2005_02 |