Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoic Acid → HCID 178473960, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoic Acid | HCID 243 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1-Acetylindolin-2-one | HCID 323719 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178473960 | HCID 178473960 | — |
반응 단계
880 mg (5 mmol) of 1-acetyl-2-indolinone and 610 mg (5 mmol) of benzoic acid are dissolved in 15 ml of DMF and after the addition of 1.8 g (5.5 mmol) of TBTU, 840 mg (5.5 mmol) of HOBt and 3.2 g (25 mmol) of N-ethyl-N,N-diisopropyl-amine are stirred for 16 hours at ambient temperature. The solution is stirred into dilute hydrochloric acid, the precipitate is suction filtered and dried at 60° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855710B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-ad8dd0735beb4c9784a5adb26d7498eb |
| 출처 메모 | uspto-grants-2005_02 |