Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → HCID 19764532, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | tert-Butyl bromoacetate | HCID 79177 | — |
| 반응물 | Methyl 2-(4-mercaptophenyl)acetate | HCID 14033178 | — |
| 생성물 | HCID 19764532 | HCID 19764532 | — |
반응 단계
Dissolve methyl 4-mercaptophenylacetate (16.4 g, 90.3 mmol) in acetone (300 mL). Add potassium carbonate (13.7 g, 99.3 mmol), potassium iodide (1.47 g, 9.03 mmol) and t-butylbromoacetate (16 mL, 99.3 mmol). Heat at reflux for 20 hours then remove 200 mL of acetone in vacuo. Dilute the residue with ethyl ether (500 mL), wash with water (2×300 mL) and brine (300 mL). Dry (MgSO4) and evaporate the solvent in vacuo. Purify by flash chromatography to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05208240 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-6f218fe89b5c4aafaca031e3af768e57 |
| 출처 메모 | uspto-grants-1993_05 |