Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → (4-(2,6-Difluorobenzyloxy)phenyl)-acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Hydroxybenzyl cyanide | HCID 26548 | — |
| 반응물 | 2-(Bromomethyl)-1,3-difluorobenzene | HCID 581435 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (4-(2,6-Difluorobenzyloxy)phenyl)-acetonitrile | HCID 21964471 | — |
반응 단계
To a solution of 4-Hydroxybenzyl cyanide (5 g, 37.5 mmol) and K2CO3 (6.74 g, 48.8 mmol) in dry DMF (20 ml) was added 2,6-Difluorobenzyl bromide (7.77 g, 37.5 mmol). The reaction mixture was stirred for 4 hours at room temperature and concentrated in vacuo. The crude residue was taken in EtOAc and washed with water and brine. The aqueous layer was washed one more time with EtOAc. The combined organic layers were dried over Na2SO4 filtered, and concentrated to provide the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06858602B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-fae8d767f9e949d2abdb4e613181892b |
| 출처 메모 | uspto-grants-2005_02 |