Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → (2-Methoxy-1-methoxymethyl-2-ethoxymethyl)-benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-(Phenylmethoxy)-1,3-propanediol | HCID 203567 | — |
| 반응물 | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| 생성물 | (2-Methoxy-1-methoxymethyl-2-ethoxymethyl)-benzene | HCID 66890845 | 97% |
반응 단계
To a solution of 2-benzyloxy-propane-1,3-diol (5.0 g, 27.4 mmol) in 5:1 THF-DMF (200 mL) at 0° C. was added NaH (1.5 g, 2.3 eq.) followed by methyl iodide (5.1 mL, 3.0 eq.). The resulting white slurry mixture was stirred at room temperature over weekend. The reaction mixture was quenched with sat. NH4Cl, extracted with EtOAc, dried over Na2SO4, filtered, concentrated and the product was purified by chromatography (50% EtOAc/hexanes) to give (2-methoxy-1-methoxymethyl-2-ethoxymethyl)-benzene (5.6 g, 97%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07868002B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-d37a0eca701849719917771c069e3349 |
| 출처 메모 | uspto-grants-2011_01 |