Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → 1-(6-Nitroindolin-1-yl)ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 6-Nitroindoline | HCID 29757 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(6-Nitroindolin-1-yl)ethanone | HCID 258566 | 100.7% |
반응 단계
6-Nitroindoline (3.0 g, 18.3 mmol) is dissolved in THF (45 mL) and Et3N (3.4 mL, 24.4 mmol) at 0° C. Acetyl chloride (1.5 mL, 21 mmol) is added dropwise. The mixture is stirred at room temperature for 30 minutes. The mixture is partitioned between EtOAc and aqueous HCl. The organic layer is dried and concentrated to yield 1-acetyl-6-nitroindoline (3.8 g, 100%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07868037B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-81270818abb845a686811bb3a462e811 |
| 출처 메모 | uspto-grants-2011_01 |