참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid | HCID 688396 | — |
| 반응물 | Bis(1-methylpiperazin-2-yl)alumanylium;hydride | HCID 18792082 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (1-Formylcyclopropyl)carbamic acid tert-butyl ester | HCID 10352385 | — |
반응 단계
N-Boc-1-amino-1-cyclopropanecarboxylic acid is dissolved in tetrahydrofuran and stirred at 0° C. under argon. Bis(N-methylpiperazinyl)aluminum hydride is added and the reaction mixture is heated to reflux overnight. Ether is then added, and the excess hydride is quenched with saturated NaCl. The aqueous phase is separated and extracted with ether. The combined organic phases are washed with 2M NaOH, 2M HCl and saturated NaCl. The solution is dried over Na2SO4 and evaporated to yield N-Boc-1-amino-1-cyclopropanecarboxaldehyde.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04701552 |
|---|
| 출처 데이터셋 | uspto-grants-1987_10 |
|---|
| ORD ID | ord-09ba152299a341178c810e4e2124543b |
|---|
| 출처 메모 | uspto-grants-1987_10 |
|---|
