Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (R)-(+)-4-(1,1,1-trifluoro-2-octyloxycarbonyl)-4'-benzyloxybiphenyl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | (R)-(+)-1,1,1-Trifluoro-2-octanol | HCID 2779099 | — |
| 반응물 | 2-Amino-3,4-dimethylpyridine | HCID 11007884 | — |
| 반응물 | 4'-(Phenylmethoxy)(1,1'-biphenyl)-4-carbonyl chloride | HCID 15084904 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (R)-(+)-4-(1,1,1-trifluoro-2-octyloxycarbonyl)-4'-benzyloxybiphenyl | HCID 22848629 | — |
반응 단계
To a solution of 4-benzyloxybiphenyl-4'-carboxylic acid chloride (1.23 g) in methylene chloride (10 ml) was added by little and little under ice-cooling a solution of (R)-(+)-1,1,1-trifluoro-2-octanol (0.96 g) ([α]D22.5 =+20.1, optical purity 96.3%ee), dimethyl-aminopyridine (0.55 g) and triethylamine (0.48 g) in methylene chloride (20 ml). The mixture was left to stand over-night at room temperature in order to complete the reaction before the mixture obtained was poured in ice-water.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05262086 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-b96a6fbc532b4d13b697817052cfd243 |
| 출처 메모 | uspto-grants-1993_11 |