Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 4-Tert-butyldimethylsilyloxymethyl-2-allylphenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | (4-(Prop-2-en-1-yloxy)phenyl)methanol | HCID 11744970 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-Tert-butyldimethylsilyloxymethyl-2-allylphenol | HCID 19934838 | — |
반응 단계
To a solution of the product of Step A (650 mg, 3.96 mmol) in CH2Cl2 (20 mL), cooled to 0° C. under nitrogen, was added triethylamine (612 mL, 4.39 mmol) and a solution of tert-butyldimethylsilyl chloride (631 mg; 4.19 mmol) in CH2Cl2 (2 mL). After stirring at room temperature for 18 hours, the reaction mixture was diluted with ethyl acetate (60 mL), washed with water, and saturated sodium bicarbonate, and then dried (MgSO4). The filtrate was concentrated in vacuo to afford 1.1 g of the title compound which was used crude in the next reaction (Rf =0.45, 5% ethyl acetate/hexanes).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05264439 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-5d8d2590ded8469297d4eab6f0d4da32 |
| 출처 메모 | uspto-grants-1993_11 |