Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-(3-(2-(2-Ethoxyethoxy)ethoxy)-1,2,5-thiadiazol-4-yl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diethylene Glycol Monoethyl Ether | HCID 8146 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole | HCID 10488164 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(3-(2-(2-Ethoxyethoxy)ethoxy)-1,2,5-thiadiazol-4-yl)pyridine | HCID 19075477 | — |
반응 단계
To a solution of 2-(2-ethoxyethoxy)ethanol (1.21 g, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thia-diazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 2 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05264444 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-178ce42713584127873dad310c6a1d6e |
| 출처 메모 | uspto-grants-1993_11 |