Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (S)-1-Boc-3-isopropylpiperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile | HCID 93865 | — |
| 반응물 | (S)-2-Isopropylpiperazine | HCID 15023839 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (S)-1-Boc-3-isopropylpiperazine | HCID 24820348 | 74.9% |
반응 단계
341 mg (2.66 mmol) 2-(S)-Isopropyl-piperazine (84) and 657 mg (2.67 mmol, 1.00 eq.) BOC-ON© (2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile) were dissolved in 20 ml 1,4-dioxane and 20 ml water. After adding 2.04 ml (14.64 mmol, 5.50 eq.) triethylamine the solution was stirred at r.t. for 24 h. Then the mixture was added to water and extracted with EtOAc. The comb. org. fractions were washed with brine, dried over Na2SO4 and evaporated. Column chromatography (CH2Cl2/MeOH (3+1)) yielded 454.9 mg (1.99 mmol, 74.90%) 3-(S)-Isopropyl-piperazine-1-carboxylic acid tert-butyl ester (85) as a clear oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06858600B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-d95c0cf80dc140a8b7f0457decee3580 |
| 출처 메모 | uspto-grants-2005_02 |