Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 1-Adamantyl 1-imidazolylmethyl ketone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Bromomethyl tricyclo[3.3.1.13,7]dec-1-yl ketone | HCID 197820 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-Adamantyl 1-imidazolylmethyl ketone | HCID 43341178 | — |
반응 단계
A solution of 5 g. of 1-adamantyl bromomethyl ketone in 10 ml. of dimethylformamide is added dropwise with stirring and ice-cooling to 7 g. imidazole in 10 ml. dimethylformamide. The resulting solution is stirred overnight at room temperature and then poured into 250 ml. water. The precipitate which forms is filtered off, washed with water and air dried. Thereafter the resulting residue is chromatographed on silica gel to effect purification. Elution with 10% acetone in dichloromethane yields 1-adamantyl 1-imidazolylmethyl ketone, M.P. 128.5°-129.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04036975 |
| 출처 데이터셋 | uspto-grants-1977_07 |
| ORD ID | ord-b47529ff2e8c445b9a39986abbb92714 |
| 출처 메모 | uspto-grants-1977_07 |