Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene, 1-bromo-3-(trifluoromethyl)- → 2,2-Dimethyl-4-(3-trifluoromethylphenyl)-2H-chromene-7-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene, 1-bromo-3-(trifluoromethyl)- | HCID 9817 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 7-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-one | HCID 600902 | — |
| 반응물 | Magnesium | HCID 5462224 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 2,2-Dimethyl-4-(3-trifluoromethylphenyl)-2H-chromene-7-ol | HCID 12071757 | 86.2% |
반응 단계
3-Bromobenzotrifluoride (61 g) in dry ether (100 ml) was added to magnesium (6.6 g) in ether (50 ml). 2,2-Dimethylchroman-4-one-7-ol (17.4 g) suspended in ether (500 ml) was added and the mixture refluxed for 16 hourss. The reaction mixture was poured into ammonium chloride solution and extracted with ether. The combined ether layers were washed with 2 N HCl (2×100 ml) and dried (MgSO4). Removal of the solvent under reduced pressure gave the title compound (25 g), m.p. 102°-106° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04153617 |
| 출처 데이터셋 | uspto-grants-1979_05 |
| ORD ID | ord-38c1fdbfa4fd41cebf2cc7138c084fcc |
| 출처 메모 | uspto-grants-1979_05 |