Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methoxyacetic Acid → 5-(Methoxymethyl)-1,3,4-thiadiazol-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methoxyacetic Acid | HCID 12251 | — |
| 반응물 | Thiosemicarbazide | HCID 2723789 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-(Methoxymethyl)-1,3,4-thiadiazol-2-amine | HCID 660844 | — |
반응 단계
Addition of phosphonyl chloride to a mixture of thiosemicarbazide and methoxyacetic acid at 60°-95° and working up of the product yields 5-amino-2-methoxymethyl-(1,3,4)thiadiazole, m.p. 177°-179° (from water). When this compound is diazotised and treated with cuprous bromide 5-bromo-2-methoxymethyl-(1,3,4)-thiadiazole results and reaction of this bromo compound with zinc dust in acetic acid at room temperature yields 2-methoxymethyl-(1,3,4)-thiadiazole, m.p. 30.5°-32°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04153704 |
| 출처 데이터셋 | uspto-grants-1979_05 |
| ORD ID | ord-bce5322235df483eaf874ea886e67157 |
| 출처 메모 | uspto-grants-1979_05 |