Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 2-Chloromethyl-3-ethoxypyridine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | (3-Ethoxypyridin-2-yl)methanol | HCID 22018715 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 2-Chloromethyl-3-ethoxypyridine hydrochloride | HCID 20474185 | — |
반응 단계
Thionyl chloride (8 cc) was added over 8 minutes to a stirred solution of 3-ethoxy-2-hydroxymethylpyridine (5.6 g) in chloroform (60 cc) at room temperature. After 11/2 hrs the mixture was evaporated to dryness and the residue was recrystallised from 0.16 M ethanolic hydrogen chloride/diethyl ether (1:1) to give 2-chloromethyl-3-ethoxypyridine hydrochloride (6.5 g) m.p. 176°-179.5°. (decomp.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04156727 |
| 출처 데이터셋 | uspto-grants-1979_05 |
| ORD ID | ord-0572a0990f034a81beadd8005107c15c |
| 출처 메모 | uspto-grants-1979_05 |